Bone Marrow Transplantation Mumbai India

It usually involves intense chemotherapy followed by an infusion of stem cells. The treatment requires close nursing and medical care for a number of weeks.

BMT
Bone marrow transplantation is potentially curative for a wide variety of disorders like
Aplastic anemia
Thalessemia major
AML
ALL
CML
MDS
Multiple myeloma
Lymphoma etc Bone Marrow / Stem cell transplant

Bone marrow transplantation (BMT), also called hematopoietic stem cell transplant, is used to increase the chance of a cure or remission for various cancers and blood disorders. What is a st

em cell transplant? A stem cell transplant may be used so that you can have intensive high-dose chemotherapy (and sometimes radiotherapy) to kill cancerous cells. The chemotherapy is higher than conventional chemotherapy and also kills the stem cells in the bone marrow that would normally make blood cells. Therefore, following the chemotherapy, you are given back (transplanted) stem cells which can then make normal blood cells again. Stem cells can be obtained from blood as well as from the bone marrow and umbilical cord. So, the term stem cell transplant is now used. What is the bone marrow, and what are stem cells and blood cells? Bone marrow
Blood cells are made in the bone marrow, by stem cells. Bone marrow is the soft sponge like material in the centre of bones. Large flat bones such as the breastbone (sternum) and pelvis contain the most bone marrow. To make blood cells constantly you need a healthy bone marrow. You also need nutrients from your diet, including iron and some vitamins. Stem cells
Stem cells are primitive (immature) cells. There are two main types in the bone marrow - myeloid and lymphoid stem cells. These derive from even more primitive cells called common pluripotent stem cells. Stem cells constantly divide and produce new cells. Some new cells remain as stem cells and others go through a series of maturing stages (precursor or blast cells) before forming into mature blood cells. Blood cells
Mature blood cells are released from the bone marrow into the bloodstream. Mature blood cells are:
Red cells- These make blood a red colour. One drop of blood contains about five million red cells. Red cells contain a chemical called haemoglobin. This binds to oxygen, and takes oxygen from the lungs to all parts of the body. White cells - The different types of white cells are called neutrophils, lymphocytes, eosinophils, monocytes, and basophils. They are part of the immune system. Their main role is to defend the body against infection. Platelets- These are tiny and help the blood to clot if we cut ourselves. Stem cells rapidly multiply to make millions of blood cells each day. Because of this they are more easily killed by chemotherapy than most other cells in the body. This is because chemotherapy drugs work by killing rapidly dividing cells (such as cancer cells). When is a stem cell transplant used for treatment? A stem cell transplant is an option which is considered for various cancer conditions. For example, for types of leukaemia, lymphoma and myeloma. A stem cell transplant is also used for some rare noncancerous blood disorders like aplastic anaemia, thalassemia major etc. There are two main types of bone marrow transplantation: autologous and allogeneic. What are types of stem cell transplant? Autologous transplant — your own hematopoietic stem cells are removed before the high dose chemotherapy or radiation is given and are then frozen for storage and later use. After your chemotherapy or radiation is complete, the harvested cells are thawed and returned to you. Allogeneic transplant — the hematopoietic stem cells come from a donor, ideally a brother or sister with a similar genetic makeup. If the patient does not have a suitably matched sibling, an unrelated person with a similar genetic makeup may be used. Non-myeloablative (mini) transplant — allows you to have less intensive chemotherapy before transplantation with allogeneic hematopoietic stem cells. This approach may be recommended if you cannot undergo standard bone marrow transplantation because of your higher age or other illnesses. Which type of transplant is best for you? — Your physician will determine whether allogeneic or autologous transplantation is best, based on many factors including the type of cancer, your age and overall health, and the availability of a suitable donor. As a general rule, autologous transplantation is associated with fewer serious side effects, since you are given cells from your own body. However, an autologous transplant may be less effective than an allogeneic transplant in treating certain kinds of cancer. In an allogeneic transplant, the donor's immune system, which is generated from hematopoietic stem cells, recognize your cells, including the tumor cells, as foreign and rejects them. This beneficial reaction is called the graft versus tumor effect. In many cancers, the immune response caused by the transplanted cells improves the overall effectiveness of the treatment. This immune response helps kill off any residual cancer cells remaining in your body. A major concern is that you will have an immune response as well, called graft versus host disease. Where are stem cells obtained from? Stem cells can be collected:
1) Bone marrow- This involves a small operation to collect some marrow from the pelvic bone.
2) Peripheral blood- Some stem cells occur in the blood (most are in the bone marrow). The stem cells in the blood can be collected (harvested) by a machine called a cell separator. The blood flow is diverted from a vein in the arm to pass through the machine which separates out the stem cells. The procedure takes about 4-6 hours. Drugs are given for a few days before this procedure to stimulate the body to make more stem cells in the bone marrow which spill out into the blood.
3) Umbilical cord of a newborn baby. How is a stem cell transplant given? It is very similar to a blood transfusion. Following the intense course of chemotherapy (and sometimes radiotherapy), the solution containing stem cells is given into one of your veins via a drip. The stem cells travel through your bloodstream and end up in your bone marrow. Here they start to make blood cells. It can take several weeks for your bone marrow to recover, to take up the transplanted stem cells, and to make enough new blood cells. During this time you will need to be in hospital and be closely monitored. You may need several blood transfusions during this time until you are making enough blood cells. Antibiotics are given to minimize the risk of infection. Also, drugs are given to help stimulate the stem cells to multiply as quickly as possible. What are the main risks of having a stem cell transplant? There is a risk of serious problems with a stem cell transplant. For example:
• Infection is the main risk. Following the intense chemotherapy, and before the time your bone marrow is working again, you have very low immunity. During this time you are at risk of serious and life-threatening infections. This is why antibiotics are given and you will be nursed away from other people until your bone marrow recovers. This can take several weeks.
• Bleeding problems from the low level of platelets after the chemotherapy.
• It you have a transplant from a donor; there is some risk that the match will not be perfect, and the donor cells may react with your body's cells. This is called graft versus host disease. This is not always serious but sometimes it can be.
• Rarely, the transplanted stem cells fail to work (Graft failure).
• There is a risk of short-term and long-term side-effects from intense chemotherapy (and/or radiotherapy). Dr Niranjan N Rathod
DM, MD, FACP (USA), Fellowship in BMT, FHCRC, Seattle, USA
Associate Director & Head of Dept of Haemato-Oncology & Bone Marrow Transplant
Nanavati Super Speciality Hospital, Vile Parle West, Mumbai. Ph-02226140046
Mobile-9930767546

Photos from Bone Marrow Transplantation Mumbai India's post

11/11/2017

Stem cell donor felicitation at Press club, Mumbai.
Thank you all donors for their invaluable contribution.

For new donor registration

http://datri.org/how-to-register/

http://www.thehindu.com/news/cities/mumbai/300-stem-cell-donors-feted-for-saving-lives/article20119887.ece

Dr Niranjan Rathod
Bone marrow transplant specialist
Nanavati Hospital, Mumbai

10/11/2017

Special day today as we felicitate our generous unrelated stem cell donors!

Many patients with blood cancers (Leukaemia, Lymphoma, Myeloma), aplastic anaemia and Thalassemia need stem cell transplant but don’t have matched donor in family. They then need to get stem cells donated by these donors through stem cell registry like DATRI. We at Nanavati Hospital are collection /apharesis centre for these transplants.

I salute to these donor who volunteer to come forward and help their fellow human beings.

🙏🏻🙏🏻🙏🏻

Dr Niranjan Rathod

http://datri.org/how-to-register/

22/08/2017

Successful Thalassemia Transplant-
Pleased to inform successful allogeneic ABO bidirectional mismatch bone marrow transplant for a 5 year old boy with Thalassemia major at Nanavati hospital. With this we have performed 5 transplant in first 4 months of start (2 Auto for Myeloma, Allo for Thalassemia, PRCA & Myelofibrosis) at Nanavati Hospital.

We have also recently collected stem cells from unrelated donor, as apharesis centre for unrelated donor registry, for international patient, successfully transplanted in Colombo.

It was possible with multidisciplinary contribution with significant roles played by Blood bank, Pathology and microbiology labs, ICU, Transplant nursing, Surgeons and other supporting departments. I take this opportunity to thank them all.

We are doing stem cells transplant for patient with malignancy like leukaemia, Myeloma, Lymphoma, MDS etc; and major hematological diseases like Aplastic anaemia, Thalassemia, PRCA, Immunodeficiency etc.

So far I have done 50 plus successful transplants in city of Mumbai.

Looking forward to your continued support to do many more transplants in future.

Thank you,

Dr Niranjan Rathod
DM,MD,FACP,Fellowship in BMT, Fred Hutch, Seattle, USA
Department of Haemato-Oncology & BMT
Nanavati Super Speciality Hospital, Mumbai
M: 9930767546

Blood Cancer & Bone Marrow Transplant Treatment-TV9

21/05/2017

Please watch my live chat show 'Arogyam Dhansampada' on blood cancers and treatment options including stem cell transplant in simple terms on TV9 Marathi which was broadcasted on 19th May at 4.30pm on following youtube link.

https://youtu.be/FKKIuSjRUcc

Please share.
Thank you,
Dr Niranjan Rathod DM MD FACP(USA)
Nanavati Super Speciality Hospital, Mumbai
Ph-02226140046

Blood Cancer & Bone Marrow Transplant Treatment-TV9 AROGYAM DHANSAMPADA : Blood Cancer & Bone Marrow Transplant Treatment Dr. Niranjan Rathod ..... For more videos go to https://www.youtube.com/tv9marathi Like...

05/05/2017

Please join us for spreading awareness about Thalassemia on this World Thalassemia day 🙏🏻

Dr Niranjan Rathod DM MD FACP
Dept of Haemato-Oncology & Bone Marrow Transplant
Nanavati Super Specialty Hospital, Mumbai

Please Contact Mr Kamlesh for free registration on 81084 92968

18/04/2017

Dear friends,

It gives me immense pleasure to announce start of my new inning as Associate Director & Head of Department at haemato-Oncology and bone marrow transplant department at Nanavati Super Speciality Hospital, Mumbai.

Radiant lifecare group's BLK Bone Marrow Transplant Centre, New Delhi is the leader in transplant in India and worldwide under able leadership of Dr Dharma Choudhary. I have had opportunity to set number of transplant units in Mumbai and really excited to take up this bigger responsibility. Together, we bring excellent infrastructure and our expertise to create state of art facility at Nanavati Super Speciality Hospital to serve patient needing bone marrow transplant and chemotherapy for haematological cancers.

Looking forward to your blessings for our endeavor!

Thank you,

Dr Niranjan Rathod DM MD FACP
Haemato-Oncology & BMT Dept
Daily OPD-Nanavati Hospital- S V Road, Vile Parle W, Mumbai.
Appointment- 02226140046/02226267636
Mobile 9930767546
Email [email protected]

05/03/2017

First successful Haplo identical stem cells transplant at Gleneagles Global Hospitals Mumbai

Unfortunately, many of patients who require bone marrow (stem cells) transplant don’t have a fully HLA matched donor, as there are only 25% of chances that one has sibling matched donor. Unrelated donor transplant are not only prohibitively expensive but also take long time which these patients don’t have. HLA, in simpler terms, is our genetic identity which we inherit from both parents as haplotype (half from each parents) and pass on to our children as haplo. So one has much higher probability of finding haplo (half) matched donor in family, expanding transplant possibilities.

One of such patients is our 8 years old boy Upendra (name changed) who was in desperate need to get transplanted as last ditch option to teat his relapsed acute leukaemia. Being single child to resources limited young parents was anything but helpful. As costly unrelated transplant was out of question, haplo (half matched) transplant although more risky was the only practical option for us at Gleneagles Global Hospitals Mumbai.

After understanding potential risks and benefits, parents finally agreed as he was running out of the time with his leukaemia refusing to budge down. Number of pre transplant tests were performed to ensure every possible preparations are made to go through this challenge. Patient was admitted in special HEPA filtered transplant rooms and received vey high dose chemotherapy to destroy his diseased bone marrow. Father was better suited as haplo donor in this case and received few injections before stem cells were removed by apharesis (filtering) procedure. Upendra was infused these stem cells on day 0, the transplant day. Wbc counts plunged to below 100 for many days, infections were controlled by using higher antibiotics. He also needed extensive support with blood transfusions, nutrients along with pain killers to keep his pain under control. Finally twelve days after infusing stem cells his own new cells are back and everything started to fall in line. And today he is ready for discharge.

I am so happy to see we could offer him a new type of high risk haplo transplant in Mumbai in almost same cost as routine allogeneic transplant. I owe credit to Fred Hutchinson Cancer Research Centre, Seattle, USA where I was trained in these type of transplant under able guidance of Dr. Prof. O’Donnell. Although higher in risk due to higher chances of graft failure and GVHD, these transplant offers great option to our patients in dire need for transplants for cure of their leukaemia, lymphoma or aplastic anaemia etc.

I would like thank to my team (nurses, ward boys, technicians) and multiple department (HLA lab, regular lab, blood bank, Nephrology, ICU, clinical services) involved in making this successful.

I hope, we will continue to offer our services to many more needy patients.

Dr Niranjan Rathod DM MD FACP (USA)
Head of Dept, Haematology & BMT,
Gleneagles Global Hospitals, Mumbai

30/01/2017

It was my privilege to be part of APICON 2017 Mumbai - annual conference of Association of Physicians of India with more than 10000 physicians from all over India attending it. I contributed with lecture and two chapters in educational books. Thank you. Dr Niranjan Rathod Haematologist

Hitguj: Dr Niranjan Rathod On Stem Cell Treatment 14th April 2016

14/04/2016

Dear friend, please watch my interview to understand bone marrow or stem cell transplant in very simple language. Thank you
Dr Niranjan Rathod

Hitguj: Dr Niranjan Rathod On Stem Cell Treatment 14th April 2016 For more info log on to www.24taas.com Like us on https://www.facebook.com/Zee24Taas Follow us on https://twitter.com/zee24taasnews

13/04/2016

Please watch my interview on Bone marrow transplant on 14 April (tomorrow) on Zee 24 tas: Hit Guj Tv Show-
Time 3:30pm To 4:00 pm
Thank you
Dr Niranjan Rathod

09/04/2016

Pleased to inform you about our first successful major ABO incompatible allogeneic peripheral blood stem cells transplant at Global Hospital Mumbai. This is my sixth transplant at Global & 34th overall in Mumbai.
Thank you for all those involved.
Dr Niranjan Rathod

03/12/2015

Pleased to inform you about our first successful Allogenic (From sibling donor) peripheral Blood stem cell transplant for patient with high risk MDS (Myelodysplastic syndrome) at Global Hospital & Transplant Centre, Parel, Mumbai.
Patient engrafted on day +12 and doing well.
This is my 30TH transplant in Mumbai.
Thankful to multidisciplinary contribution by blood bank, pathology lab, HLA lab, nursing staff, admin and support staff.
Regards,
Dr Niranjan Rathod DM MD FACP
Hematologist
Global Hospital, Mumbai

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